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E-bike cable tourism is notorious for friction, it’s worth checking. You also should check hanger for alignment, a new hanger is not the same as a properly aligned hanger, and often the hanger will need tweaking to account for frame tolerances etc. set is up is right, things aren’t worn, and the hanger is straight, then cable routing is next stop.

A few things I have not seen mentioned that may be worth considering, just to further understand this problem, as its something pros even had to deal with in their lifetime. Grip texturing, this can cause your gloves to bunch up a lot. At least it did for me. I found if I wore gloves I needed pronounced ridging for my glove to have good traction/grip. But this caused bunching. So if I went smooth gripped, I had less grip/traction with gloves. I settled on good smooth rubber and no gloves. More dangerous but I like my goldilocks setup. Everyone...

I found that smaller diameter grips work better in almost every way - although thicker grips are cushier, I find myself gripping on them harder because they feel vague; moreover, I can hold on more securely and relaxedly on thinner grips since I can wrap more of my hand around the bar. That said, grips are pretty cheap so you can easily try out both thick and thin to see which one you like better. You might also consider push-on grips - super thin but softer and absorbs more vibration than even the thickest lock-ons. As for adjusting cockpit, one...

You might be gripping the bar too hard, Should be loose and relaxed, fluid like playing a piano

When buying gloves buy something that feels a bit too tight when you try them on in the shop as they stretch out to fit your hand and not bunch up.

I found I had to size down on gloves to avoid them bunching up like you mention. This might just be a hand anatomy thing, but I use fairly thin gloves and size down until I find a size where it's not an issue. You don't want them so tight they are putting pressure or compressing your hand, but if they are bunching up I'd argue you are probably on gloves too large. You can also try to put them in the dryer to shrink them somewhat, I do this every so often just to wash them and bring them...

All good tips so far, and I agree that playing with different diameters of grips might help with the bunching problem you have. You also mentioned that you're experiencing pain "on the pinky area of my palm, on the part that is opposite of my knuckle. It starts to blister which sucks, so far it hasn't gotten bad enough to stop me from riding but on a really long day I think it would..." which I take to mean pain on your hand in this location (please let me know if I'm wrong): Any sort of "hotspot" pain in your...

see if you can have some smartie or fast person watch you ride. I’ll bet the culprit is your suspension. Is your bike too big? Weird stem? Bars too far out there? Mess around with your bars and your body position, there may be something there…cool thing about that stuff is you can always go back Concentrate on heavy feet, light hands. And / or lay off the brakes! I’ve been lucky to have ridden with good riders who can hear my gripe and suggest “more air in your fork” or whatever. Suspension can be counterintuitive, and nothing’s more important.

Thinnest gloves possible that are preformed to the curve of your hand. I've had good luck with Fox Flexairs (the ones with perforated palm - they also make ones without holes that use a thicker material), Leatt 1.0s, & Outdoor Research Freewheel. That and just ride a lot to build up calluses.

I used to get this where my hand was rubbing on the outer lock ring. Switching to push on grips and grips with just the inner lock ring resolved the issue for me.

So like, between your finger and the grip is there your gloves bunch? It seems most riders prefer a thin grip, but I’ve found a thicker grip to be beneficial. Might help if that’s your issue. odi rogues have been good for me.